师资介绍 朱伟明 教授

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朱伟明 教授

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朱伟明，男，1965年2月生，博士、教授、博士生导师，从事海洋天然药物研究。已培养硕士3名，协助培养硕士16名、博士5名、博士后1名；在读硕士生8名、博士生4名。已发表论文58篇，其中SCI收录30篇；申请国家发明专利15项（授权6项）。联系电话0532-82032065，传真：0532-82033054、82032065，E-mail: weimingzhu@ouc.edu.cn 3 m. k. u5 n; b0 G# m

教育 Education:

l 1981-1985年：武汉大学化学系，毕业并获得理学学士学位。B.Sc. in Chemistry, Wuhan University l 5 e/ ?- r6 z& l5 I1985-1988年：武汉大学化学系，毕业并获得理学硕士学位。M.S. in Organic Chemistry, Wuhan University l 1997-2001年：中科院昆明植物研究所，毕业并获得理学博士学位。 Ph. D. in Natural Products, Kunming Institute of Botany, Chinese Academy of Science 工作经历 Experience: l / h; |! p3 q0 e! a' U& u1988-2003年：云南师范大学化学系助教、讲师、教研室主任、副教授、教授，主要从事有机化学的教学及科研工作。Assistant lecturer, lecturer, laboratory head, associate professor and professor in Organic Chemistry, Yunnan Normal University. l 2001-2003年：中国科学院上海有机化学研究所博士后，从事活性产物喷脑皂甙元Pennogenin及其衍生物合成研究。Postdoctoral research in Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science. l 2003年至今：中国海洋大学医药学院教授、博士生导师，主要从事海洋天然药物的研究及相关教学工作。Professor in Natural Products, Ocean University of China. 社会兼职 Social Position: l 2005年至今：中国药学会海洋药物专业委员会委员，中国微生物学会海洋微生物专业委员会委员。A committee member of specialized committee in marine drugs, Chinese Pharmaceutical Association；A committee member of specialized committee in marine microbiology, Chinese Society for Microbiology. 5 b" w! ]5 i3 ~, X% X5 al , i6 [9 J8 y- @3 u2004年至今：山东省药学会中药和天然产物专业委员会专业委员。A committee member of specialized committee in the traditional Chinese medicine and natural products, Shandong Pharmaceutical Association. 4 L. T" \3 q4 o获奖 Award: l 1993年：获云南省首届高校青年教师课堂教学比赛省级一等奖。Awarded the first grade prize in the classroom teaching competition of colleges and universities young teachers by Yunnan Province. l 1997年：获授奖云南师范大学教学成果三等奖。Awarded the 3rd grade prize of teaching outcomes by Yunnan Normal University. 5 ~8 k3 I/ b& L& N9 gl V- y5 X- O. `2006年：获第九届中国药学会施维雅青年药物化学奖。Awarded the 2006´ CPA-Servier Young Investigator Awards in Medicinal Chemistry by Chinese Pharmaceutical Association.

著书 Book Published:

朱伟明，谢笑天，吴增元，《有机化学学习技巧》，云南科技出版社，1995年。Zhu Weiming, Xie Xiaotian, Wu Zengyuan, “Some Methods for Learning Organic Chemistry”, Yunnan Press of Science and Technology, 1995. 研究领域 Research field: l ! ^8 k. z* j2 A5 V4 ]从可再生的海洋生物资源中发掘创新药物先导化合物To discovery new hits and lead compounds from the reproducible marine biotic resources, especially from marine-derived microbes, micro-algae and halotolerant microorganisms by means of integrated screening methods 6 J8 Z l" v% B8 v- |& p利用生物学与化学相结合的集成筛选方法，从海洋微生物、耐盐（酸、碱）微生物中筛选并发现具有重要生物活性的药物先导化合物以及新的可替代资源。 l 中药药理作用的物质基础研究Investigations of pharmacological compounds in the traditional Chinese medicine 与药理学家合作，利用现代分离分析技术和结构测定技术，研究传统中药（主要是藏药）的物质基础，发现其有效成分。 l 天然药物的优化 To discovery new leads by structural modification of new hits 利用化学方法，对所获得的具有重要生物活性的天然产物进行结构修饰，探讨其构效关系，获得临床候选药物。 8 @" P( e* g% a+ Z" b+ y- F研究课题 Research programs: l “海洋微生物中抗癌等活性先导化合物的发现和优化”（No. 2003AA624020,2003－2005，863计划），已通过验收。Discovery of leading compounds with anti-tumor activities from marine-derived microorganisms (No.2003AA624020,2003-2005, Chinese National Programs for High Technology Research and Development) ! b% u0 x3 d! Hl 9 e, y0 A3 x% ]' {( V“嗜盐微生物抗肿瘤活性成分的探索性研究”（No.30470196, 2004－2005，国家自然科学基金），已结题。Primary studies on the antitumor constituents of halophiles (No. 30470196, 2004-2005, Chinese National Natural Science Fund) l 9 L& [: H% k u5 O, U. i% z5 E“新的蛋白激酶C抑制剂ACT-007衍生物的合成及其抗癌构效关系研究”（No.30572246, 2006－2008，国家自然科学基金）。Syntheses and anti-tumor activities of the derivatives of the new PKC inhibitor, ACT-007 and their structure-active relationship(No.30572246, 2006-2008, Chinese National Natural Science Fund) l 0 D0 j v1 }8 O“嗜盐微生物抗肿瘤活性成分的研究”（No.30670219, 2007－2009，国家自然科学基金）。Studies on the anti-tumor constituents from the halophilic and halotolerant microorganisms(No.30670219, 2007-2009, Chinese National Natural Science Fund) 9 E) x0 H3 K1 |5 R! [代表性文章 Selected Publications: : [: g4 N7 Y, t! z. s1. Liu, Rui; Gu, Qianqun; Zhu, Weiming; Cui, Chengbin; Fan, Guotao; Fang, Yuchun; Zhu, Tianjiao; Liu, Hongbing. 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans. J. Nat. Prod. 2006, 69(6): 871-875. 2. + h* C7 T* i0 v0 k+ sWeizhong Liu, Qianqun Gu, Weiming Zhu, Chengbin Cui, Chengbin Cui, Guotao Fan, Tianjiao Zhu, Hongbing Liu and Yuchun Fang, Penicillones A and B, two novel polyketides with tricyclo [5.3.1.03, 8] undecane skeleton, from a marine-derived fungus Penicillium terrestre. Tetrahedron Lett.2005, 46(30): 4993-4996. 3. Xiaoxian Han, Chengbin Cui, Qianqun Gu, Weiming Zhu, Hongbing Liu, Jingyan Gu and Hiroyuki Osada, ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp. 007. Tetrahedron Lett.2005, 46(36): 6137-6140. / O# o8 w" v$ j0 s5 }4. Rui Liu, Weiming Zhu, Yapeng Zhang, Tianjiao Zhu, Hongbing Liu, Yuchun Fang, Qianqun Gu, A new diphenyl ether from marine-derived fungus Aspergillus sp. B-F-2. J. Antibiot. 2006, 59(6): 362-365. 5. 1 b9 b6 U; w/ j& { [Weizhong Liu, Qianqun Gu, Weiming Zhu, Chengbin Cui, Guotao Fan, Dihydrotrichodimerol and Tetratrichodimerol, Two New Bisorbicillinoids, from a Marine-derived Penicillium terrestre, J. Antibiot. ! N6 i; |+ C4 A' ~8 T, ^2005, 58(10): 621-624. # e! P3 X4 p* K" f, U0 K6. Hong Ren, Li Tian, Qianqun Gu, and Weiming Zhu, Secalonic acid D; A Cytotoxic Constituent from Marine Lichen-derived Fungus Gliocladium sp. T31. Arch. Pharm. Res. 2006, 29(1): 59-63. 7. 8 b. y. f: \; f* [3 d* J! J4 n- \Bingui Wang, Weiming Zhu, Xiaoming Li, Zhongjian Jia and Xiaojiang Hao, Rubupungenosides A and B, Two Novel Triterpenoid Saponin Dimers from the Aerial Parts of Rubus pungens, J. Nat. Prod.2000, 63(6): 851-858. & u n$ V3 A4 W2 M; B8. Weiming Zhu, Huajie Zhu, Weisheng Tian, Xiaojiang Hao and Charles U.Pittman Jr., The Selective Dehydroxylation of 20-Hydroxyecdysone by Zn Powder and Anhydrous Acetic Acid, Synthetic Comm. 2002, 32(9): 1385-1391. : [, Y V/ A, x9. " U9 A: O/ x" b+ B* t6 |' l ]Weiming Zhu, Shunlin Li, Yuemao Shen, Xianjiang Ning, Bitao Zhao, and Xiaojiang Hao, The sesquiterpenoid from Polyalthia cheliensis Hu, Heterocycles, 2002, 57(3): 529-534. 8 H! U) k8 d/ l. ^; E" @10. 9 _2 v! |& V+ f! n5 D" bWeiming Zhu, Chunhua Lu, Yue Wang, Jun Zhou, Xiaojiang Hao, Monoterpenoids and Their Glycosides from Winchia calophylla,J. Asian Nat. Prod. Res., 2004, 6(3): 193?198.